The Movement Disorder Society Evidence‐Based Medicine Review Update: Treatments for the motor symptoms of Parkinson's disease
Identifieur interne : 000157 ( France/Analysis ); précédent : 000156; suivant : 000158The Movement Disorder Society Evidence‐Based Medicine Review Update: Treatments for the motor symptoms of Parkinson's disease
Auteurs : Susan H. Fox [Canada] ; Regina Katzenschlager [Autriche] ; Shen-Yang Lim [Malaisie] ; Bernard Ravina [États-Unis] ; Klaus Seppi [Autriche] ; Miguel Coelho [Portugal] ; Werner Poewe [Autriche] ; Olivier Rascol [France] ; Christopher G. Goetz [États-Unis] ; Cristina Sampaio [Portugal]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Acupuncture, Acupuncture Therapy, Amantadine, Amine oxidase (flavin-containing), Antiparkinson Agents (classification), Antiparkinson Agents (therapeutic use), Clozapine, Deep Brain Stimulation, Deep brain stimulation, Dopamine agonist, Evidence-Based Medicine, Evidence-based medicine, Fetal Stem Cells (transplantation), Humans, Levodopa, Motor Activity, Motor system disorder, Nervous system diseases, Pallidotomy, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (rehabilitation), Parkinson Disease (surgery), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Physical exercise, Randomized Controlled Trials as Topic, Speech, Thalamus (surgery), Transferases, Treatment, Treatment Outcome, acupuncture, amantadine, anticholinergics, catechol‐O‐methyl transferase inhibitors, clozapine, deep brain stimulation, dopamine agonists, evidence‐based medicine, exercise, levodopa, monoamine oxidase inhibitors, neurosurgery, occupational therapy, physical therapy, speech therapy.
- MESH :
- chemical , classification : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- rehabilitation : Parkinson Disease.
- surgery : Parkinson Disease, Thalamus.
- therapy : Parkinson Disease.
- transplantation : Fetal Stem Cells.
- Acupuncture Therapy, Deep Brain Stimulation, Evidence-Based Medicine, Humans, Motor Activity, Pallidotomy, Randomized Controlled Trials as Topic, Treatment Outcome.
Abstract
The objective was to update previous evidence‐based medicine reviews of treatments for motor symptoms of Parkinson's disease published between 2002 and 2005. Level I (randomized, controlled trial) reports of pharmacological, surgical, and nonpharmacological interventions for the motor symptoms of Parkinson's disease between January 2004 (2001 for nonpharmacological) and December 2010 were reviewed. Criteria for inclusion, clinical indications, ranking, efficacy conclusions, safety, and implications for clinical practice followed the original program outline and adhered to evidence‐based medicine methodology. Sixty‐eight new studies qualified for review. Piribedil, pramipexole, pramipexole extended release, ropinirole, rotigotine, cabergoline, and pergolide were all efficacious as symptomatic monotherapy; ropinirole prolonged release was likely efficacious. All were efficacious as a symptomatic adjunct except pramipexole extended release, for which there is insufficient evidence. For prevention/delay of motor fluctuations, pramipexole and cabergoline were efficacious, and for prevention/delay of dyskinesia, pramipexole, ropinirole, ropinirole prolonged release, and cabergoline were all efficacious, whereas pergolide was likely efficacious. Duodenal infusion of levodopa was likely efficacious in the treatment of motor complications, but the practice implication is investigational. Entacapone was nonefficacious as a symptomatic adjunct to levodopa in nonfluctuating patients and nonefficacious in the prevention/delay of motor complications. Rasagiline conclusions were revised to efficacious as a symptomatic adjunct, and as treatment for motor fluctuations. Clozapine was efficacious in dyskinesia, but because of safety issues, the practice implication is possibly useful. Bilateral subthalamic nucleus deep brain stimulation, bilateral globus pallidus stimulation, and unilateral pallidotomy were updated to efficacious for motor complications. Physical therapy was revised to likely efficacious as symptomatic adjunct therapy. This evidence‐based medicine review updates the field and highlights gaps for research. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23829
Affiliations:
- Autriche, Canada, France, Malaisie, Portugal, États-Unis
- Illinois, Midi-Pyrénées, Occitanie (région administrative), Tyrol (Land), Vienne (Autriche), État de New York
- Innsbruck, Toulouse, Vienne (Autriche)
- Université de médecine d'Innsbruck
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ISTEX:EFC08EE13DB12B91723CF6C75EAAAFDF983AB074Le document en format XML
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Level I (randomized, controlled trial) reports of pharmacological, surgical, and nonpharmacological interventions for the motor symptoms of Parkinson's disease between January 2004 (2001 for nonpharmacological) and December 2010 were reviewed. Criteria for inclusion, clinical indications, ranking, efficacy conclusions, safety, and implications for clinical practice followed the original program outline and adhered to evidence‐based medicine methodology. Sixty‐eight new studies qualified for review. Piribedil, pramipexole, pramipexole extended release, ropinirole, rotigotine, cabergoline, and pergolide were all efficacious as symptomatic monotherapy; ropinirole prolonged release was likely efficacious. All were efficacious as a symptomatic adjunct except pramipexole extended release, for which there is insufficient evidence. For prevention/delay of motor fluctuations, pramipexole and cabergoline were efficacious, and for prevention/delay of dyskinesia, pramipexole, ropinirole, ropinirole prolonged release, and cabergoline were all efficacious, whereas pergolide was likely efficacious. Duodenal infusion of levodopa was likely efficacious in the treatment of motor complications, but the practice implication is investigational. Entacapone was nonefficacious as a symptomatic adjunct to levodopa in nonfluctuating patients and nonefficacious in the prevention/delay of motor complications. Rasagiline conclusions were revised to efficacious as a symptomatic adjunct, and as treatment for motor fluctuations. Clozapine was efficacious in dyskinesia, but because of safety issues, the practice implication is possibly useful. Bilateral subthalamic nucleus deep brain stimulation, bilateral globus pallidus stimulation, and unilateral pallidotomy were updated to efficacious for motor complications. Physical therapy was revised to likely efficacious as symptomatic adjunct therapy. This evidence‐based medicine review updates the field and highlights gaps for research. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Canada</li><li>France</li><li>Malaisie</li><li>Portugal</li><li>États-Unis</li></country><region><li>Illinois</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Tyrol (Land)</li><li>Vienne (Autriche)</li><li>État de New York</li></region><settlement><li>Innsbruck</li><li>Toulouse</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H." last="Fox">Susan H. Fox</name></noRegion><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H." last="Fox">Susan H. Fox</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name></region><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></country><country name="Malaisie"><noRegion><name sortKey="Lim, Shen Ang" sort="Lim, Shen Ang" uniqKey="Lim S" first="Shen-Yang" last="Lim">Shen-Yang Lim</name></noRegion></country><country name="États-Unis"><region name="État de New York"><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name></region><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name></country><country name="Portugal"><noRegion><name sortKey="Coelho, Miguel" sort="Coelho, Miguel" uniqKey="Coelho M" first="Miguel" last="Coelho">Miguel Coelho</name></noRegion><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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